Opinions are those of the authors and not of Repligen Corporation

Published 2013, 88 pages



Continuous Bioprocessing: Current Practice and Future Potential

Continuous Biomanufacturing: Current Practice and Future Potential

The opinions expressed in this book are those of the authors and not of Repligen Corporation.

  1. Introduction to Continuous Manufacturing:Technology Landscape and Trends
    Eric S. Langer & Ronald A. Rader, BioPlan Associates

  2. A Brief History of Perfusion Biomanufacturing
    Jerry Shevitz and  John Bonham-Carter

  3. Bioreactor Configuration and Operation
    Christel Fenge, Jörg Weyand, Gerhard Greller, Thorsten Adams,
    Sartorius Stedim Biotech

  4. How to Develop a Perfusion Process
    Véronique Chotteau, Royal Technical University, KTH

  5. Case Study: Optimized Perfusion
    Shaun Eckerle, Gallus BioPharmaceuticals

  6. Process Intensification Approaches for Cost Sensitive Protein Applications
    Willem Adriaan de Jongh, Expres2ion Biotechnologies

  7. Impact of Single-use Technology on Continuous Bioprocessing
    William G. Whitford, Thermo Fisher Scientific

  8. Continuous Multicolumn Chromatography Processes
    Marc Bisschops, Tarpon Biosystems

  9. Continuous Processes: Economic Evaluation
    Andrew Sinclair & Andrew Brown, BioPharm Services

  10. Vision: Integrating Upstream and Downstream in a Fully Continuous Facility
    Tim Johnson, Genzyme

Special Report on Continuous Bioprocessing: Upstream, Downstream, Ready for Prime Time?
by Angelo DePalma
BioProcessing International
May 11, 2016

Prepacked Chromatography Columns: Evaluation for Use in Pilot and Large-Scale Bioprocessing
by Shaun Grier and Saani Yakubu
BioProcess International
April 2016

WuXi Biologics Expands Perfusion Cell Culture Capabilities using ATF 10 System
In 2016, WuXi Biologics will add perfusion-based commerciall manufacturing services using the ATF 10 System coupled with 1,000 L single-use bioreactors.
Fall 2015

Quantitation of LONG®R3 IGF-I during production and purification of recombinant proteins from cell culture
by Thomas H. Ermak, Ph.D. and Amanda Flies, Ph.D.
Cell Sciences, Inc.
April 2015

Continuous Manufacturing: A Changing Processing Paradigm
By Randi Hernandez
BioPharm International, Volume 28, Issue 4
April  2015

A Novel Seed-Train Process: Using High Density Cell Banking, a Disposable Bioreactor, and Perfusion Technologies
By Benjamin Wright, Mike Bruninghaus, Mike Vrabel, Jason Walther, Neha Shah, Seul-A Bae, Timothy Johnson,Jin Yin, Weichang Zhou and Konstantin Konstantinov
BioProcess International
March 2015

Developing an upstream process for a monoclonal antibody including medium optimization
by Sevim Duvar, Volker Hecht, Juliane Finger, Matthias Gullans, Holger Ziehr
BioMed Central Ltd
June 2013

Shrinking the Costs of Bioprocess Development
by Gary Lye Jurgen Hubbuch Tim Schroeder Eric Willimann
BioProcess International
October 2009

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